CDC73
Associated conditions:
- Endocrine cancer
- Renal/urinary tract cancer
CDC73 makes parafibromin, a protein that helps control gene activity and cell division. Genetic changes in this gene are associated with an autosomal dominant condition called hyperparathyroidism-jaw tumour syndrome, raising the risk of overactive parathyroid glands, rare parathyroid cancer, and jaw and kidney tumours. Knowing your genetic status enables regular calcium and imaging checks.
Conditions linked to CDC73
Endocrine cancer
Endocrine cancers affect hormone-producing glands such as the thyroid, parathyroid, adrenal glands or pancreatic islet cells. Inherited variants can drive tumours in one or more of these glands, so awareness supports periodic hormone testing and imaging to catch changes early.
Renal/urinary tract cancer
Cancers of the kidney and urinary tract develop in the kidneys, ureters or bladder lining. Several inherited variants raise their risk, so carriers may be offered periodic kidney imaging and urine testing to catch tumours early.
