DSG2
Associated conditions:
- Arrhythmia
- Cardiomyopathy
DSG2 makes desmoglein-2, a molecular rivet that holds heart muscle cells firmly together at their junctions. Genetic changes in this gene weaken these connections and are associated with an autosomal dominant condition called arrhythmogenic cardiomyopathy, in which muscle is replaced by fat and scar. Knowing your genetic status enables monitoring that helps prevent dangerous heart rhythms and sudden death.
Conditions linked to DSG2
Arrhythmia
An arrhythmia is an abnormal heart rhythm. Inherited forms can cause fast, irregular or dangerous rhythms and, rarely, sudden collapse, so carriers benefit from heart-rhythm testing, sometimes medication, and avoiding specific triggers.
Cardiomyopathy
Cardiomyopathy is disease of the heart muscle that can make it thickened, enlarged or weakened. Inherited forms can affect the heart’s pumping or rhythm, so carriers are monitored with heart scans and ECGs and treated early to protect heart function.
