SERPINA1
Associated conditions:
- Alpha-1 antitrypsin deficiency
SERPINA1 makes alpha-1 antitrypsin, a protein that shields the lungs from enzymes that would otherwise digest their delicate tissue. Genetic changes in this gene, especially when both copies carry a variant, are associated with an autosomal recessive increased risk of early emphysema and liver disease as the abnormal protein builds up in liver cells. Knowing your genetic status enables avoiding smoking and monitoring lung and liver health.
Conditions linked to SERPINA1
Alpha-1 antitrypsin deficiency
Alpha-1 antitrypsin deficiency means the body makes too little of a protein that protects the lungs and liver from enzyme damage. It can lead to early emphysema, especially with smoking, and sometimes liver disease, so avoiding smoking and monitoring lung and liver health matter most.
