One sample. A lifetime of answers.
Start by screening 180+ genes for insights that you and your doctor can act on. No noise, no uncertain variants, no raw-data overwhelm
Breast cancer 13 genes
Genes linked to inherited breast and related cancer risk.
Some variants in these genes raise lifetime risk of breast and related cancers. Finding one early means enhanced screening and risk-reducing options can start years before anything would surface on its own.
- ATMBreast cancer, Pancreatic cancer, Prostate cancer
- BARD1Breast cancer
- BRCA1Breast, gynecologic, pancreatic, prostate cancer, and fanconi anemia
- BRCA2Breast, gynecologic, pancreatic, prostate cancer, and fanconi anemia
- CDH1Breast cancer, Colorectal cancer, Gastric cancer
- CHEK2Breast cancer and prostate cancer
- NF1Breast, endocrine, Gastrointestinal stromal tumors (GIST), and nervous system/brain cancer
- PALB2Breast, ovarian and pancreatic cancer
- PTENBreast cancer, Colorectal cancer, Endocrine cancer, Gynecologic cancer, Nervous system/brain cancer, Renal/urinary tract cancer, Melanoma
- RAD51CBreast cancer, Gynecologic cancer
- RAD51DBreast cancer, Gynecologic cancer
- STK11Breast cancer, Colorectal cancer, Gastric cancer, Gynecologic cancer, Pancreatic cancer
- TP53Breast cancer, Endocrine cancer, Gastrointestinal cancer, Genitourinary cancer, Gynecologic cancer, Hematologic cancer, Nervous system/brain cancer, Skin cancer, Sarcoma
Colorectal cancer 16 genes
Genes behind hereditary bowel cancer and polyposis.
Some variants in these genes raise lifetime risk of polyps and/or hereditary bowel cancer. Knowing your status sets the right age to start colonoscopy and how often to repeat it.
- APCColorectal cancer, Endocrine cancer, Gastric cancer, Nervous system/brain cancer, Pancreatic cancer, Sarcoma
- AXIN2Colorectal cancer
- BMPR1AColorectal cancer, Gastric cancer, Pancreatic cancer
- EPCAMColorectal cancer, Gastric cancer, Gynecologic cancer, Nervous system/brain cancer, Pancreatic cancer, Prostate cancer, Renal/urinary tract cancer
- GREM1Colorectal cancer
- MLH1Colorectal cancer, Gastric cancer, Gynecologic cancer, Nervous system/brain cancer, Pancreatic cancer, Prostate cancer, Renal/urinary tract cancer
- MSH2Colorectal cancer, Gastric cancer, Gynecologic cancer, Nervous system/brain cancer, Pancreatic cancer, Prostate cancer, Renal/urinary tract cancer
- MSH3Colorectal cancer, polyposis
- MSH6Colorectal cancer, Gastric cancer, Gynecologic cancer, Nervous system/brain cancer, Pancreatic cancer, Prostate cancer, Renal/urinary tract cancer
- MUTYHColorectal cancer, polyposis and reporting of carrier status
- NTHL1Colorectal cancer
- PMS2Colorectal cancer, Gastric cancer, Gynecologic cancer, Nervous system/brain cancer, Pancreatic cancer, Prostate cancer, Renal/urinary tract cancer
- POLD1Colorectal cancer, polyposis
- POLEColorectal cancer, polyposis
- RNF43Polyposis
- SMAD4Colorectal cancer, Gastric cancer, Pancreatic cancer
Other cancer 40 genes
Inherited variants that raise risk across several cancers.
Some gene variants raise lifetime risk of cancer across several organs at once. Identifying them focuses surveillance on the cancers you are actually predisposed to, rather than screening blind.
- AIPPituitary adenomas
- BAP1Renal/urinary tract cancer, Melanoma
- BRIP1Gynecologic cancer and fanconi anemia
- CDC73Endocrine cancer, Renal/urinary tract cancer
- CDK4Melanoma
- CDKN1BEndocrine benign tumours
- CDKN2ANervous system/brain cancer, Pancreatic cancer, Melanoma
- CTNNA1Stomach cancer
- DDX41Hematological cancer
- DICER1Endocrine cancer, Gynecologic cancer, Nervous system/brain cancer, Renal/urinary tract cancer, Sarcoma
- EGFRLung cancer
- FHRenal/urinary tract cancer, sarcoma and Fumarate Hydratase Deficiency
- FLCNRenal/urinary tract cancer
- HOXB13Prostate cancer
- KITGastrointestinal stromal tumors
- LZTR1Schwannomatosis
- MAXEndocrine cancer
- MEN1Endocrine, nervous system/brain and pancreatic cancer
- METRenal/urinary tract cancer
- MITFMelanoma
- NF2Nervous system/brain cancer, schwannomatosis
- PDGFRAGastrointestinal stromal tumors
- POT1Melanoma, leukemia, brain cancer
- PRKAR1AEndocrine cancer, Nervous system/brain cancer, Sarcoma
- PTCH1Nervous system/brain and skin cancer, benign tumours
- RB1Melanoma, Retinoblastoma, Sarcoma
- RETEndocrine cancer
- RUNX1Hematological cancer
- SDHAEndocrine cancer, sarcoma, gastrointestinal stromal tumors (GIST)
- SDHAF2Endocrine cancer
- SDHBEndocrine and renal/urinary tract cancer, sarcoma gastrointestinal stromal tumors (GIST)
- SDHCEndocrine, and renal/urinary tract cancer, sarcoma and gastrointestinal stromal tumors (GIST)
- SDHDEndocrine, and renal/urinary tract cancer, sarcoma and gastrointestinal stromal tumors (GIST)
- SMARCA4Gynecologic cancer
- SMARCB1Nervous system/brain cancer, Renal/urinary tract cancer
- SUFUNervous system cancer
- TMEM127Endocrine cancer
- TSC1Nervous system/brain cancer, Pancreatic cancer, Renal/urinary tract cancer
- TSC2Nervous system/brain cancer, Pancreatic cancer, Renal/urinary tract cancer
- VHLEndocrine cancer, Nervous system/brain cancer, Pancreatic cancer, Renal/urinary tract cancer
Cardiomyopathy 38 genes
Genes that can silently thicken or weaken the heart muscle.
Gene variants in inherited cardiomyopathy genes can thicken or weaken the heart muscle silently for years. Early detection enables monitoring and treatment before heart failure or a sudden cardiac event.
- ACTC1Cardiomyopathy
- ACTN2Cardiomyopathy
- CACNA1CArrhythmia, Cardiomyopathy
- CAV3Cardiomyopathy
- CRYABCardiomyopathy
- CSRP3Cardiomyopathy
- DESArrhythmia, Cardiomyopathy
- DMDCardiomyopathy
- DSC2Arrhythmia, Cardiomyopathy
- DSG2Arrhythmia, Cardiomyopathy
- DSPArrhythmia, Cardiomyopathy
- EMDArrhythmia, Cardiomyopathy
- FHL1Cardiomyopathy
- FLNCArrhythmia, Cardiomyopathy
- GDF2Arrhythmia, Cardiomyopathy
- JUPArrhythmia, Cardiomyopathy
- LAMP2Cardiomyopathy
- LMNAArrhythmia, Cardiomyopathy
- MYBPC3Cardiomyopathy
- MYH7Cardiomyopathy
- MYL2Cardiomyopathy
- MYL3Cardiomyopathy
- MYLKCardiomyopathy
- NKX2-5Cardiomyopathy
- PKP2Arrhythmia, Cardiomyopathy
- PLNArrhythmia, Cardiomyopathy
- PRKAG2Arrhythmia, Cardiomyopathy
- RBM20Cardiomyopathy
- RYR2Arrhythmia, Cardiomyopathy
- SCN5AArrhythmia, Cardiomyopathy
- TMEM43Cardiomyopathy
- TNNC1Cardiomyopathy
- TNNI3Cardiomyopathy
- TNNT2Cardiomyopathy
- TPM1Cardiomyopathy
- TTNTTN-cardiomyopathy
- TTRTTR-cardiomyopathy
- VCLCardiomyopathy
Heart rhythm disorders 12 genes
Genes behind inherited arrhythmias and sudden cardiac risk.
Gene variants in channelopathy genes can trigger dangerous arrhythmias in otherwise healthy people. A known variant guides medication, activity and device decisions that prevent sudden cardiac death.
- BAG3Aortopathy, Arrhythmia
- CALM1Arrhythmia
- CALM2Arrhythmia
- CALM3Arrhythmia
- CASQ2Arrhythmia
- HCN4Arrhythmia
- KCNE1Arrhythmia
- KCNH2Arrhythmia
- KCNJ2Arrhythmia
- KCNQ1Arrhythmia
- TECRLArrhythmia
- TRDNCatecholaminergic Polymorphic Ventricular Tachycardia
Other heart and circulation 37 genes
Genes affecting the aorta, blood vessels and cholesterol.
Gene variants affecting the aorta, blood vessels and lipids can raise the risk of aneurysm, early heart disease and stroke. Early awareness drives the right imaging and lipid management before damage accumulates.
- ACTA2Aortopathy
- ACVRL1High blood pressure
- ANKRD26Thrombocytopenia
- APOA1Cardiovascular disease
- APOBHypercholesterolaemia
- BMPR2High blood pressure
- CAV1High blood pressure
- CBSHomocystinuria
- COL1A1Vascular Ehlers-Danlos syndrome, Classical Ehlers-Danlos syndrome, Osteogenesis imperfecta
- COL3A1Vascular Ehlers-Danlos syndrome
- COL5A1Classical Ehlers-Danlos Syndrome
- COL5A2Classical Ehlers-Danlos Syndrome
- ELNConnective tissue disorder, Aortopathy
- ENGHigh blood pressure
- ETV6Thrombocytopenia
- F11Thrombophilia
- F2Thrombophilia
- F5Thrombophilia
- F9Hemophilia
- FBN1Aortopathy
- GLAHigh blood pressure
- KCNK3Pulmonary arterial hypertension
- LDLRHypercholesterolaemia
- LDLRAP1Hypercholesterolaemia
- LOXAortopathy
- MYH11Aortopathy
- PCSK9Hypercholesterolaemia
- PRKG1Aortopathy
- PROCThrombophilia
- PROS1Thrombophilia
- SERPINC1High blood pressure
- SMAD3Aortopathy
- SMAD9Pulmonary arterial hypertension
- TGFB2Aortopathy
- TGFB3Aortopathy
- TGFBR1Aortopathy
- TGFBR2Aortopathy
Blood and immune health 8 genes
Genes shaping clotting, iron handling and immune defence.
Gene variants can affect how your blood clots, how you handle iron and how your immune system defends you. Knowing them informs prevention of clots, iron overload and recurrent infection.
- G6PDG6PD deficiency
- HAMPHemochromatosis type 2
- HFEHemochromatosis
- HJVHemochromatosis type 2A
- HMBSAcute intermittent porphyria
- MEFVFamilial Mediterranean Fever
- SLC40A1Hemochromatosis type 4
- TFR2Hemochromatosis type 3
Brain, nerve and muscle health 4 genes
Inherited neurological and neuromuscular conditions.
Several neurological and neuromuscular conditions have a clear genetic basis. Early identification supports monitoring, family planning and timely access to emerging therapies.
- CACNA1SHypokalemic periodic paralysis
- GAAPompe disease
- GCH1Dystonia
- RYR1Central core disease
Liver and kidney health 7 genes
Metabolic, liver and kidney genes that can cause quiet damage.
Variants in metabolic, liver and kidney genes can quietly damage these organs over decades. Detecting them early supports protective monitoring and lifestyle change while it still makes a difference.
- ATP7BWilson disease
- COL4A3Alport syndrome
- COL4A4Alport syndrome
- COL4A5Alport syndrome
- PKD1Polycystic kidney disease
- PKD2Polycystic kidney disease
- SERPINA1Alpha-1 antitrypsin deficiency
Hormones and metabolism 6 genes
Endocrine and metabolic genes affecting hormones and cholesterol.
Inherited endocrine and metabolic variants can disrupt hormones, cholesterol and how your body produces energy. Early detection guides screening and treatment to head off downstream disease.
- ABCD1X-Linked Adrenoleukodystrophy
- BCHEButyrylcholinesterase deficiency
- BTDBiotinidase deficiency
- GCKMaturity onset diabetes of the young
- OTCOrnithine transcarbamylase deficiency
- CYP27A1Cerebrotendinous xanthomatosis
Skin, bones and connective tissue 1 genes
Genes shaping skin, joints, bones and blood vessels.
Connective-tissue and skeletal genes shape skin, joints, bones and blood vessels. Identifying a variant supports proactive musculoskeletal and vascular care before problems compound.
- CYLDCYLD cutaneous syndrome
Diabetes 3 genes
Genes behind inherited diabetes
Gene variants in these genes raise lifetime risk of diabetes in adulthood. Finding one early means enhanced screening can start before any symptoms would surface on its own.
- HNF1AMODY3
- HNF1BMODY5
- HNF4AMODY1
Gene and condition summaries are plain-language and for education only, not a diagnosis or medical advice.
Why this matters
Invisible risks
These risks don't show up in a blood test and can't always be predicted by family history.
Early = actionable
Earlier screening, preventive medication and lifestyle changes targeted to your specific risk.
Clinically filtered
Only findings that can inform your action plan are reported, not raw variants or uncertain data.